Holiday led all scorers with 35 points.
Nick Young and Evan Turner both had 20 points apiece for the Sixers.
Anthony dropped 25 points while Amar’e Stoudemire had 20 for New York.
Besides Anthony and Stoudemire, no other Knicks scored more than eight points.
The Sixers shot 50.7% from the field.
The Knicks out-rebounded the Sixers 47-34.
The 76ers only committed 11 turnovers to the Knicks 16.
There were 20,540 fans in attendance.
The 76ers get back at it on Monday night against the Memphis Grizzlies at 7:00 pm at the Wells Fargo Center.
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